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KMID : 1189420190320020001
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2019 Volume.32 No. 2 p.1 ~ p.10
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Inhibitory Effects of KM1701 on Airway Cell Infiltration in OVA-Induced Mouse Model
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Lim Soon-Min
Choi Han-Seok
Kim Sang-Back
Kim Ye-Jin
Kang Ji-Sung
Shin Myoung-Sook
Kim Kyung-Jun
Hwang Bang-Yeon
Koo Bon-Am
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Abstract
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Objectives : The objective of present study is to evaluate anti-inflammatory and anti-allergic effects of Perilla(Perilla frutescens; Labiatae, PF), the roots of Peucedanum praeruptorum(PP) and the root of Scutellaria baicalensis(SB) in vitro and anti-asthmatic effects of mixture of PF, PP and SB(PS) on ovalbumin (OVA)-induced asthma in BALB/c mice.
Methods : Anti-inflammatory and anti-allergic effects were observed on the lipopolysaccharide(LPS) treated RAW 264.7 cells through Nitric Oxide(NO) production and RBL-2H3 cells through β-hexosaminidase. Anti-asthmatic effects were observed on the number of inflammatory cells in bronchoalveolar lavage fluid(BALF) and the level of IgE in serum on OVA-induced BALB/c mice.
Results : The treatment of PF, PP and SB(12.5, 25, 50, 100㎍/㎖) resulted in a significant inhibition of NO production in RAW 264.7 cells and mast cell degranulation in RBL-2H3 cells. Oral administration of PS(400㎎/㎏/day) resulted in a significant reduction in the numbers of eosinophils in BALF and level of IgE in serum.
Conclusion : The oral administration of PS is effective in ameliorating the eosinophilic infiltration in vivo and thus can be a good therapeutic candidate for allergic asthma.
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KEYWORD
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KM1701, Airway Cell Infiltration, OVA-induced Mouse Model
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